Biology of Ageing Archives - Longevity Simplified

Light clinical infographic illustrating protein leverage, showing a balance scale with whole protein foods on one side driving stable satiety, reduced cravings and stable blood sugar, and ultra-processed foods on the other side driving overeating, unstable blood sugar and accelerated ageing.

Protein Leverage Explained: Why Protein Controls Hunger, Blood Sugar and Ageing Your appetite is wired to seek protein first. When […]

Clinical infographic showing a blood glucose graph with spikes and crashes linked to oxidative stress, inflammation, mitochondrial strain, stress hormones, energy swings and accelerated ageing, illustrating why unstable blood sugar increases metabolic and biological stress.

Biology of Ageing

Blood Sugar Variability Explained: Why Spikes and Dips Accelerate Ageing

Simon

Blood Sugar Variability Explained: Why Spikes and Dips Accelerate Ageing It’s not just average blood sugar that matters. Repeated glucose

Light clinical infographic showing a central clock balancing day and night eating patterns, comparing circadian-aligned meals with improved glucose control, energy use and metabolic flexibility versus late eating linked to insulin resistance, inflammation, disrupted hormones and fat gain.

Biology of Ageing

Chrononutrition Explained: Why Meal Timing Shapes Metabolism, Hormones and Longevity

Simon

Chrononutrition Explained: Why Meal Timing Shapes Metabolism, Hormones and Longevity What you eat matters — but when you eat also

Light clinical infographic illustrating IGF-1 as a central growth signal, showing muscle and tissue building on one side and ageing and inflammation trade-offs on the other, with balance scales highlighting moderation through protein intake, calories, exercise and fasting for long-term longevity.

Biology of Ageing

IGF-1 Explained: Growth Signalling, Muscle Preservation and Longevity Trade-Offs

Simon

IGF-1 Explained: Growth Signalling, Muscle Preservation and Longevity Trade-Offs Insulin-like Growth Factor-1 (IGF-1) drives growth, tissue repair and muscle maintenance

Light clinical infographic comparing mTOR and AMPK as metabolic switches, showing mTOR driving growth and muscle building with insulin and protein signals, and AMPK promoting repair, energy conservation and fat burning through exercise, fasting and metabolic demand, balanced on a central ageing scale.

Biology of Ageing

mTOR & AMPK Explained: Two Metabolic Switches That Shape Ageing, Energy and Longevity

Simon

mTOR & AMPK Explained: Two Metabolic Switches That Shape Ageing, Energy and Longevity mTOR and AMPK act like opposing cellular

Light clinical infographic showing overtraining syndrome leading to hormonal dysregulation, mitochondrial strain and accelerated ageing, with balance scales illustrating too much training stress versus too little recovery, and icons for fatigue, elevated heart rate, poor sleep and inflammation.

Biology of Ageing

Overtraining and Ageing: When More Backfires on Recovery, Hormones and Longevity

Simon

Overtraining and Ageing: When “More” Backfires on Recovery, Hormones and Longevity Training is meant to build resilience — but chronic

Light clinical infographic illustrating exercise as hormesis, showing the cycle of stress, recovery and adaptation, with balance scales highlighting too little stimulus versus too much stress, and icons for movement, sleep quality and aerobic base supporting long-term resilience.

Biology of Ageing

Exercise as Hormesis: Why Intensity Needs Recovery for Long-Term Resilience

Simon

Exercise as Hormesis: Why Intensity Needs Recovery for Long-Term Resilience Exercise is a powerful stress signal that builds resilience —

Light clinical infographic illustrating heat shock proteins activating cellular repair pathways, with icons representing protein folding, mitochondrial protection, exercise, heat exposure and cellular resilience in a clean science-based design.

Biology of Ageing

Heat Shock Proteins Explained: Why Small Stress Makes Your Cells More Resilient

Simon

Heat Shock Proteins Explained: Why Small Stress Makes Your Cells More Resilient Heat shock proteins are cellular repair molecules that

Light clinical infographic showing the gut microbiome connected to immune cells inside a human torso, illustrating how gut barrier integrity, microbial balance and lifestyle factors influence inflammation, ageing and immune resilience.

Biology of Ageing

The Gut–Immune Link: How Your Microbiome Shapes Inflammation, Ageing and Resilience

Simon

The Gut–Immune Link: How Your Microbiome Shapes Inflammation, Ageing and Resilience Your gut isn’t just about digestion. It trains your

Light clinical infographic illustrating senolytics targeting senescent “zombie” cells, with visual sections showing animal evidence, limited human data, safety uncertainties, and lifestyle levers such as exercise, nutrition, sleep and recovery.

Biology of Ageing

Senolytics Explained: What They Are (and What’s Still Unproven)

Simon

Senolytics Explained: What They Are (and What’s Still Unproven) Senolytics aim to selectively remove senescent “zombie” cells. The science is

Light clinical infographic comparing a younger and older human figure to illustrate immune ageing (immunosenescence), showing reduced thymus activity, memory T-cell buildup, mitochondrial decline and higher chronic inflammation, alongside lifestyle actions that support immune resilience.

Biology of Ageing

Immune Ageing Explained: What Immunosenescence Means (and How to Support Your Immune System)

Simon

Immune Ageing Explained: What Immunosenescence Means (and How to Support Your Immune System) As you age, immunity becomes less precise:

Light clinical infographic comparing a younger and older human figure with cool versus warm glowing organs, illustrating inflammaging and how rising chronic inflammation with age is influenced by immune ageing, oxidative stress and metabolic instability, alongside lifestyle actions that help reduce inflammatory load.

Biology of Ageing

Inflammaging Explained: Why Inflammation Rises With Age (and What Actually Helps)

Simon

Inflammaging Explained: Why Inflammation Rises With Age (and What Actually Helps) Inflammaging is the slow, chronic rise in baseline inflammation